ANAESTHETIC MOLECULES

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Partition coefficients of some anaesthetic-like molecules between water and smectic mesophases of dipalmitoyl phosphatidylcholine.

The work of Meyer (1899) and Overton (1899) at the turn of the century, made it clear that the relationship between the biological activity of a molecule, e.g. in producing anaesthesia, and its chemical structure was dependent in part on the ability of that molecule to dissolve preferentially in the hydrophobic rather than the hydrophilic regions of an organism. It has been, therefore, a preocc...

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Anaesthetic monitoring: clinical practice in anaesthetic rooms and theatres.

Twenty anaesthetic rooms and operating theatres in Northern Ireland were visited in both 1990 and 1992. Data was collected on the availability and use of anaesthetic monitoring. In the anaesthetic rooms there were few pulse oximeters. In the theatres more monitors were available and in use. Some change in practice had occurred between 1990 and 1992, notably an increase in the monitoring of vent...

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Anaesthetic gas Scavenging

ThEATRE Possible adverse health effects are an increased risk of spontaneous abortion in females, the increased likelihood of male anaesthetists to father daughters, decreased fertility, a potential increase in haematological malignancy, renal and liver dysfunction and decreased mental performance. One explanation for these effects is inhibition of methionine synthase by nitrous oxide, causing ...

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Anaesthetic complications of acromegaly.

The anaesthetic risks of acromegaly include difficulties in airway management, hypertension, and cardiac, gastrointestinal and renal problems. To estimate the incidence of major complications in this rare group of patients, we reviewed 28 patients with acromegaly who had pituitary tumour excision over a 10-yr period. Each patient was matched for age, weight and sex to a non-acromegalic patient ...

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Anaesthetic management of achondroplasia.

We report a patient with achondroplasia who presented for emergency Caesarean section. Endotracheal intubation was not difficult. The reaction of this patient to drugs such as thiopentone and tubocurarine, judged on body weight basis, was normal.

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 1974

ISSN: 0007-0912

DOI: 10.1093/bja/46.3.181